Brafv600e immunohistochemistry in papillary thyroid carcinomas: relationship between clinical and morphological parameters
نویسندگان
چکیده
منابع مشابه
The relationship between the BRAFV600E mutation in papillary thyroid microcarcinoma and clinicopathologic factors
BACKGROUND The BRAF(V600E) mutation, which accounts for about 60-80% papillary thyroid carcinoma(PTC), has been identifiedas a prognostic marker for risk stratification of PTC patients. However, the BRAF(V600E) mutation as a prognostic marker in papillary thyroid microcarcinoma (PTMC) is unclear. METHODS We performed a retrospective review of 101 patients who underwent surgery for PTMC. We st...
متن کاملClinical implication of the BRAFV600E mutation in papillary thyroid carcinoma
BACKGROUND The BRAFV600E mutation is the most common genetic alteration in papillary thyroid carcinoma (PTC). In recent studies, the BRAFV600E mutation has been associated with poor clinicopathological characteristics, such as lymph node metastasis, extrathyroidal extension, and advanced stage. However, other studies have failed to establish an association between the BRAFV600E mutation and cli...
متن کاملDetection of Plasma BRAFV600E Mutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas
PURPOSE The BRAF(V600E) mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid carcinoma (PTC). The purpose of this study was to determine the clinical significance of free circulating mutant BRAF(V600E) in predicting the advanced disease of PTC. MATERIALS AND METHODS Seventy seven matched tumor and plasma samples obtained from patients with both beni...
متن کاملAssociations between BRAFV600E and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta-analysis
BACKGROUND The objective of this study is to perform a meta-analysis to evaluate the associations between the BRAF(V600E) mutation status and aggressive clinicopathological features and poor prognostic factors in papillary thyroid cancer. METHODS A literature search was performed within the PubMed, MEDLINE, Web of Science databases, and EMBASE databases using the Medical Subject Headings and ...
متن کاملCross-Regulation between Oncogenic BRAFV600E Kinase and the MST1 Pathway in Papillary Thyroid Carcinoma
BACKGROUND The BRAF(V600E) mutation leading to constitutive signaling of MEK-ERK pathways causes papillary thyroid cancer (PTC). Ras association domain family 1A (RASSF1A), which is an important regulator of MST1 tumor suppressor pathways, is inactivated by hypermethylation of its promoter region in 20 to 32% of PTC. However, in PTC without RASSF1A methylation, the regulatory mechanisms of RASS...
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ژورنال
عنوان ژورنال: Turkish Journal of Pathology
سال: 2019
ISSN: 1018-5615,1309-5730
DOI: 10.5146/tjpath.2018.01448